Sentence examples for integration of upstream from inspiring English sources

Therefore, first one has had integration of upstream and downstream processes.

Coherent results were obtained in transient transfection studies that monitored integration of upstream metabolic signals on the promoter of the MMP13 gene.

Cardiac hypertrophy and CHD are mediated by transcription factor integration of upstream stress signals, and Mef2d-deficient mice have an attenuated hypertrophic response to cardiac stress [ 34].

The prevalence of MEK1/2-ERK1/2 MEK1/2-ERK1/2andoss these KEGG maps likely reflects the role of these signal transducers in the integration of numerous upstream signacross

Based on these data, we cloned the 675 bp fragment containing the functional urg1 promoter (Purg1) into several PCR-based targeting vectors for straightforward integration of the promoter upstream of selected genes in their normal chromosomal locations (Figure 3).

Integration of F-MuLV upstream of Fli-1 is shown to block differentiation of this cell line [ 17].

In the majority of cases, MMTV activates Int gene expression as a result of proviral integration upstream of the promoter region.

The finding of disproportionate integrations into this intron of BACH2 in proliferating and persisting cells strongly suggest that this event favors cell survival: HIV integration just upstream of the start of the coding sequence could lead to promoter insertion-mediated activation (16) and thus dysregulation of the BACH2 gene.

The Global Health Initiative, Paris Declaration, World Bank Sector Wide Approaches, the International Health Partnership Plus a are models of "upstream" integration and coordination at the national level and higher, where donors, partner governments and other implementers harmonize financing and work together to develop and implement national health plans [ 1- 4].

We have localized the T55 transgene integration site upstream of Hes1 and show that the transgene is expressed in a subset of Hes1 expression sites, including pharyngeal mesoderm of the SHF.

The funnel shape around the proteins' native states can describe mechanisms of upstream signal integration and downstream response.