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Although local recurrence and neck lymph node metastases account for most of the deaths from this disease, only 10 20% of patients benefit from the integration of systemic chemotherapeutic therapy, with marginally improved survival and considerable toxic effects [2], [3].
The other hypothalamic nucleus involved in the primary detection and integration of systemic information into behavioral response to control energy balance is the VMH.
Arguments usually address the risk of local recurrence, enabling a curative resection and facilitating sphincter-sparing surgery, rather than the integration of systemic chemotherapy and the high risk of metastatic disease.
This review identifies the motility of end buds as a unique developmental marker that represents the successful integration of systemic and local mammotrophic influences, and covers relevant advances in ductal growth regulation, extracellular matrix (ECM) remodeling, and cell adhesion in the inner end bud.
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The patients receiving placebo had no improvement in PFS or OS with PCI.Trends toward improved PFS and OS were seen in patients receiving PCI and sunitinib, thus supporting the need for further prospective research evaluating the integration of maintenance systemic therapy and PCI for patients with ES-SCLC.
Analysis identified the Transfer of Technology approach as still the predominant approach to aquaculture innovation; and, even with the integration of elements of Systemic approaches, most studies remain focused on the farm level and are technology driven.
Further studies are required to address the integration of the system in a more systemic manner and to investigate and describe the distinct experiences throughout the various Brazilian states and municipalities.
Certain features of iron metabolism make it a suitable subject for systems analysis aiming at integration of cellular and systemic dynamics and regulation.
Alvarez, J. M., Vidal, E. A. & Gutiérrez, R. A. Integration of local and systemic signaling pathways for plant N responses.
However, proper problem specific integration of research within systemic, transdisciplinary programs remains a challenge of its own [ 93].
It suggests that effective integration of genomic and systemic uniqueness of drug targets captured dynamic regulation properties of cancer drug targets, leading to the improved prediction.
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