Survival of organisms in dynamic environments requires accurate perception and integration of signals.
Integration of signals could increase the specificity of the sensor and enable detection of a combination of ligands that may indicate environmental or developmental processes when detected together.
The G1 phase is central to the integration of signals that regulate both the exit from the cell division cycle to differentiation and the reactivation of cell proliferation.
In living organisms, the integration of signals from the environment and the molecular computing leading to a cellular response are orchestrated by Gene Regulatory Networks (GRN).
Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers.
Met forms heterodimers with other receptor tyrosine kinases including members of the epidermal growth factor (EGF) receptor family; this crosstalk between Met and other growth factor receptors permits integration of signals during the process of phenotypic change [38].
In the combination of decisions or visual cognition systems, as well as the integration of signals from different sensors, statistical means or weighted means such as M 1, M 2, or M 3 are often used [1, 3, 4, 5, 8].
The integration of signals in the inner ear from the surrounding tissues is essential for its proper development.
The changing number of these kinases over time is often the result of a feedback regulation from the integration of signals stimulating receptors [49].
This stabilization event most likely occurs by integration of signals emanating from non-aligned and aligned filopodia which sense different extent of adhesion surface on the line pattern.
Integration of signals at the enhancer level has been shown to be an essential mechanism to achieve specific and coordinated responses [55].
