Hagoort and coworkers argue that the early interaction of word-form and content information is related to ongoing lexical selection, whereas the later N400 effect is associated to semantic integration of selected candidates.
We have developed a new algorithm named PHLAT to discover the most probable pair of HLA alleles at four-digit resolution or higher, via a unique integration of a candidate allele selection and a likelihood scoring.
Moreover, the gene-level resolution provided by the genome sequences allowed us to identify boundaries of viral integration and candidates of horizontally transferred genes.
Integration of the resulting candidate gene list with expression data of neuroblastoma progenitor cells pinpointed CADM1 as a compelling candidate gene.
Our study clearly demonstrate the interest of systems biology approaches to study cancer and its consequences, more particularly by the integration of heterogeneous sets of candidate regulators.
Currently, for promising drug candidates integration of data from hERG assays with information from other pre-clinical safety screens remains essential.
Starting from these 217 candidates, integration of additional information collected by MESSA, such as the consensus between different predictors, other sequence features (transmembrane helices), features of the close homologs, the predicted function and spatial structures, allows us to propose a more confident list of 84 proteins that are likely secreted by the Sec pathway.
To understand the anatomical basis of integration of PN input by candidate output neurons of the LH (LHNs), we examined their dendritic arborizations.
In the present work, we demonstrated an efficient integration of the forward-predicted candidate regulatory relationships with the NCI60 panel of parallel miRNA and mRNA expression datasets, giving rise to a genome-scale combinatorial network of transcriptional regulations and miRNA regulations in human cancer.
These sequences will greatly facilitate the identification of candidate genes, allowing integration of both genetic and genomic (functional and structural) data.
