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There seems to be little or no preference for integration in specific genes, which suggests that insertional mutagenesis generally is not involved in the generation of cervical cancer cells [ 13- 15].
The second possibility raised by the recent findings of a clear enrichment for near identical or multiple IS in specific sites of a gene is that integration in specific genes provides a survival signal for cells carrying an HIV provirus in specific genes in those cells.
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All these categories were barely or not at all over-represented in the post-infusion dataset, indicating no preferential survival in vivo of cells harboring integrations in specific gene categories, particularly cell growth and proliferation and cancer (blue bars in Figure 6).
The optimization results of demand supply matching demonstrate that the integration of a solar heat collector achieves a better integrated performance than the solar PV integration in the specific case study.
Integration sites can be used as markers of clonality to study the clonal dynamics of transduced cells in vivo, and provide important clues to predict the potential genotoxicity of MLV integration in a specific cell or disease context [12], [22], [24], [25], [26].
In combination with other '-omics' technologies, such as transcriptomics and metabolomics, proteomics explores different aspects of disease, and the different pillars of observations facilitate the data integration in disease-specific networks.
Although, as Reviewer 2 suggests, changes in membrane time constant can have an influence on the integration of synaptic inputs in specific time windows (resonance), the fact that the increase in time constant is not associated with significant changes in Rin and Cm led us to regard this result with caution.
Sex-specific integration in the lateral horn may underlie sex-specific behaviors.
For example, electrophysiological studies suggest that gamma band (higher than 30 Hz) synchronization is responsible for the integration of brain regions involved in specific aspects of stimulus processing.
The inhibition of MAGL activity, with the theoretical increase of central content of 2-AG, may modulate the activation of structures involved in pain perception and pain integration in an animal model specific for migraine.
As with HG003, we now observed a high background of non-transposase catalyzed ermR colonies in RN4220 attB+, consistent with a role for phage-mediated att-site specific integration in increasing background.
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