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For instance, in gene therapy trials using γ-RVs to treat SCID-X1 immunodeficiency, multiple patients developed T-cell acute lymphoblastic leukemia that was directly attributable to the RV randomly integrating next to, and activating the LMO-2 oncogene.
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Genomic analyses revealed the presence of one complete prophage sequence, Фlj6026 (LJP0764-LJP0819), which is integrated next to tRNA loci at ∼900 kbp within the DPC6026 genome.
If they have been integrated next to other related regulatory proteins or transcriptional factors, their selection might have been favored [ 55].
Only a minority of these prophages (51) integrated next to tRNAs, as is common in other clades (Williams 2002), even if all identified phage integrases were tyrosine recombinases.
For example, the low firing rates of L2/3e and L6e neurons in our model have different structural origins: L2/3e effectively integrates, next to the excitatory inputs from L2/3e and L4e, inhibitory inputs from all layers.
The colony color assay utilizes an ADE2 reporter integrated next to the right telomere of chromosome V. Reporter strains were plated onto YPD medium, incubated for 2 days, and then transferred to 4°C until the color development was sufficient for photometric detection.
CEO Devon Wijesinghe said me that by integrating Next Principles' product, Insightpool can help marketers get smarter about actually driving sales, for example by targeting their efforts at consumers who are actually ready to make a purchase.
Eye-tracking is a potentially influential feature that could grow in value especially in the personal and ubiquitous device areas, and Intel probably hopes to secure a functional advantage by integrating next-generation interface technologies.
Integrating next-generation sequencing technology with the development of resequencing analysis provides an opportunity to quickly identify large numbers of population-specific SNPs (Huang et al. 2010).
Integrating next-generation sensors such as LIDAR is extremely complicated.
Together with openBIS MIMAS is pioneer in integrating next-generation sequencing techniques.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com