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The software is composed by a core module, which implements basic algorithms and data structures, plus a user interface module that integrates the analyses into the Cytoscape interface.
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Additionally, we studied the conservation of the B3 domain during evolution, and integrated the analyses of B3 evolution with the well-characterized families AP2/EREBP (APETALA 2/ethylene responsive element binding protein) and ARF.
This can be achieved either by integrating the analyses using a single platform, such as the multiplex immunoassay method described above, or by using sophisticated bioinformatic and biostatistical methods to integrate the metabolite and proteomic data acquired using different platforms.
All three researchers then discussed the themes identified from both sites; ELA integrated the analyses and all three agreed on the final set of themes, sub-themes and their interrelations.
Our work integrated the approaches, analysing both ground deformation and microseismic data in order to reach a more complete understanding of rock damage at depth and mechanisms of instability.
The application of the MMR paradigm in the health outcomes field can be rooted in the widely accepted definition by Tashakkori and Creswell: "Mixed Methods Research is a research in which the investigator collects and analyses data, integrates the findings, and draws inferences using both qualitative and quantitative approaches or methods in a single study or program of inquiry" [8] (pp.2).
The Integrated Analysis of Content and Construct Validity (IACCV) approach establishes a unified model that seamlessly integrates the content and construct validity analyses [ 20].
Mixed methods research is that in which 'the investigator collects and analyses data, integrates the findings, and draws inferences using both qualitative and quantitative approaches or methods in a single study or a program of inquiry' [ 5].
Unlike other dedicated meta-analysis packages, Meta-Analyst integrates the capabilities to perform meta-analyses of binary or continuous outcomes and diagnostic or prognostic tests, combining the functionality of software such as MIX and Meta-DiSc.
Only for combined data all samples could be integrated into the analyses for each data set.
Students' achievement data was collected by means of an authentic computer-based CIL assessment administered to students in the eighth year of schooling (Fraillon et al. 2014) and has been integrated into the analyses as a latent construct of the five plausible values at both the individual as well as the school level.
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