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Such integrated simulation framework is intended to exploit engineering models outside their specific discipline, enabling cross-functional collaboration and help decision makers understand how a design can contribute in satisfying customer and stakeholders needs during the lifecycle of a PSS.
A case study based on an actual public bus route in Singapore is used to demonstrate the usefulness of such an integrated simulation framework.
The overall aim of this study was to develop an integrated simulation framework for toxicity, dose intensity, disease progression, and cost effectiveness for castration-resistant prostate cancer treatment with eribulin as a proof-of-concept.
Such patient characteristics can be leveraged into an integrated simulation framework to assess the specific impact of, for example, increased probability to experience toxicities, or decreased probability for treatment response.
Second, during early clinical development, uncertainty related to toxicity or efficacy profiles may still be relatively high, and in such cases sensitivity analysis could be considered to quantify the impact of uncertainty in toxicity parameters on any inference derived from an integrated simulation framework.
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Firstly, the intermediate model based integrated model framework is designed to support the uniform modeling and integrated visualization of multidisciplinary simulation data.
Since the knowledge of analyzing simulation output for decision making is not inherently captured in the simulation modeling methodology, a framework that integrates simulation and knowledge-based decision analysis is needed.
The article also reviews instructional frameworks for integrating simulation tools and other shared resources into courses.
An alternative modeling framework is proposed, integrating simulation models and optimization strategies that take into account double-parking derived vehicle obstruction.
Therefore, this paper provides a way to investigate the charging load simulation from a CS perspective and proposes a simple but novel integrated "traffic-power" simulation framework.
19 The previously developed pharmacodynamic model for eribulin-induced neutropenia, which was also integrated in the simulation framework, was based on a much larger pooled dataset from multiple phase I, II, and III studies including a total of 1,579 patients 8 who were predominantly treated for breast cancer.
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