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Elevated integrated relaxation pressure (IRP) on esophageal high-resolution manometry (HRM) identifies obstructive processes at the esophagogastric junction (EGJ).
Elevated intrabolus pressure identifies obstructive processes when integrated relaxation pressure is normal on esophageal high-resolution manometry.
GERD: gastro-esophageal reflux disease; IPF: idiopathic pulmonary fibrosis; LESP: lower esophageal sphincter pressure; LESRP: lower esophageal sphincter residual pressure; IRP: integrated relaxation pressure.
Integrated relaxation pressure (IRP) reports mean EGJ pressure that is measured with an electronic equivalent of a sleeve sensor in four continuous or non-continuous seconds of relaxation in the ten-second window after deglutitive LES relaxation.
Comparisons were made between standard and composite swallow interpretations.Correlation between the two systems was high for mean distal contractile integral (DCI, r2 ≥ 0.9) but lower for integrated relaxation pressure (IRP, r2 = 0.7).
BACKGROUND EGJOO is a heterogenous disorder defined by high-resolution manometry parameters of elevated integrated relaxation pressure with preserved esophageal peristalsis.
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