The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood.
When these cells were transplanted into the subretinal space of RCS rats, the cells displayed polarity and integrated well into the host retina.
These include in particular proliferation and planar-cell-polarity affecting pathways that are integrated through the centrosome-templated primary cilium (PDGFR α, Wnt-, and Hedgehog (Hh -signalling).
These findings highlight the need for models that explain how the signals that regulate stomatal development are integrated and how they act to regulate cell polarity, the cell cycle and, ultimately, cell fate.
Figure 2 shows integrated EL intensity as a function of applied voltage for both voltage polarities.
Interestingly, some of the molecules involved in presynaptic assembly also play roles in regulating axon polarity and outgrowth, suggesting that different neurodevelopmental processes are molecularly integrated.
On a personal level, what this means is that the polarities within our Being are rising to the surface to be dealt with, acknowledged and integrated so that we may move into wholeness.
The polarity markers GFP-Cdc42, Cdc42-mCherrySW and GFP-Sec4 (Chen et al., 2012) are integrated at the URA3 locus.
In summary, mammary branching morphogenesis, acinar polarity, alveogenesis and lactation require a coordinated signaling between the ECM, hormones and growth factors, which are integrated by β1 and β4.
Everything is integrated.
Acquisitions were poorly integrated.
