This necessitates a smoother, better-integrated interplay between the functional roles of planning and operations to leverage the capabilities of probabilistic analysis in both realms.
The fatty acid (FA) profile of blood and tissues integrates the complex interplay between dietary intake of FAs and endogenous FA metabolism, and has been shown to be associated with risk of type 2 diabetes in a number of studies [ 1– 6].
This fully integrated model resolves a complex interplay between heat transfer at the macroscale and grain structure evolution and microsegregation formation at the mesoscale.
These cycles usually form metabolic hubs where many functionally distinct pathways are integrated; an analysis of the interplay between supply and demand around these cycles is crucial for our understanding of metabolic regulation.
It would be interesting for future work to integrate the accumulating information about the complex interplay between the hippocampus and the mEC to better understand the consequences of hierarchical grid organization for the hippocampal place system.
There is an urgent need for integrating both approaches and to study the interplay between behavioral mechanisms and evolution (Bonabeau et al. 1997; Page and Mitchell 1998; McNamara and Houston 2009).
High priority will be given to projects that integrate multi-investigator, multidisciplinary approaches with a high degree of interplay between computational and experimental approaches.
To fully understand the interplay between the genome, epigenome and transcriptome, existing datasets need to be integrated with information about additional mechanisms of epigenomic regulation, including the emerging non-coding transcriptome and higher-order chromatin organization.
A rigorous approach would be to integrate cell-cycle driving pathways into the model, as was done to investigate the interplay between cell cycle and DNA-damage response pathways regulating cell cycle arrest.
Here we have integrated gene centered knowledge from epidemiological and mechanistic environmental research in an attempt to discover the interplay between genetic and environmental mediators of phenotype at the pathway level.
