Nevertheless, it serves as a hypothesis provoking and building process that should encourage integrated analyses of AD pathogenesis.
We also performed integrated analyses of SNPs, expression array and cytotoxicity data [ 18, 23].
Chumnanpuen et al. [ 15] performed integrated analyses of transcription factors controlling lipid biosynthesis and the lipidome in yeast.
We conducted preplanned integrated analyses of combined radiographic data from PSUMMIT-1 and PSUMMIT-2 phase 3, randomised, controlled trials.
Several studies have proposed integrated analyses of microarray data and protein-protein interaction (PPI) networks to find diagnostic subnetwork markers.
From these integrated analyses, mutational landscapes are emerging that have revealed novel oncogenic signatures and cancer driver mutations [ 2- 4].
These integrated analyses not only improve the prediction accuracy but also shed light on the biological pathways involved in the pathogenesis of the diseases.
In the near future, a greater understanding of methyl-CpG binding protein function will require integrated analyses of genome-wide binding profiles, long-range interactions in chromatin, and the regulatory role of posttranslational modifications.
In a personalized medicine project on ovarian cancer in collaboration with The Cancer Genome Atlas project, Dr. Sun performed integrated analyses on the multidimensional genomic, epigenetic, and clinical data of 316 high-grade serous ovarian cancer cases.
Integrated analyses of these observational data are essential in research, which is peculiar to STP.
Integrated analyses of multi-omics datasets can provide comprehensive understanding of cellular function, and can enable systems biology-driven and mathematical model-guided strain engineering.
