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In the present study, we investigated the mechanism by which such transcription factors integrate to regulate gene expression.
It is important to note that there is not a dominance of genetics or epigenetics, but the two molecular processes integrate to regulate biology.
With the majority of disease-associated SNPs mapping to non-coding, potentially regulatory regions 100, it is important to gain a better understanding of how multiple TF binding events integrate to regulate transcription in time and space.
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How these signals are integrated to regulate TAZ under complex circumstances is very intriguing.
The brain represents a key site where environment stimuli and internal signals are integrated to regulate vertebrate physiology and behavior.
Based on these findings, it appears that PIFs function as cellular 'hubs' where environmental signals are integrated to regulate plant responses to the changing environmental conditions.
The stage of plant development, signals from photoperiod, temperature, gibberellins and other factors are integrated to regulate flowering time in sorghum [ 5].
Great interest is currently focused on understanding the prodigious architecture of the mammary gland and how the vast network of signals, fundamental in sustaining this architecture, is integrated to regulate the normal organ and becomes disrupted in cancer.
The phosphoswitch provides a general mechanism to integrate diverse stimuli to regulate circadian period.
Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined.
Additional recent findings suggest that Kv channel accessory subunits can respond to changes in intracellular Ca2+ or metabolism and thereby integrate signaling pathways to regulate Kv channel expression and properties.
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