At present, MK-2 is recognized as a new member of the DNA damage checkpoint kinase family that functions in parallel with Chk1 and Chk2 to integrate DNA damage responses and cell cycle arrest [ 46].
It allows to integrate failures, damages, as well as the possibility of regeneration, into operational availability assessment.
By integrating this damage evolution model with the synergistic damage mechanics approach for stiffness degradation, the stress-strain response of the studied laminates is predicted.
With wireless sensors being integrated into damage detection systems, practical issues need to be addressed in conjunction with the detection algorithm employed.
This may be explained by the fact that arterial stiffness integrates the damage of cardiovascular risk factors (classical and nonclassical) on the aortic wall over a long period of time, whereas cardiovascular risk factors can fluctuate in time, and their values, recorded at the time of risk assessment, may not reflect their real impact in damaging the arterial wall (4).
The Department of Defense should integrate civilian collateral damage into the formal "lessons learned" process, so that it can refine planning, training and weapons requirements -- something that it has never done before.
BARD1 architecture and plasticity imparted by the ANK-BRCT linker are suitable to allow the BARD1 C-terminus to act as a hub with multiple binding sites to integrate diverse DNA damage signals directly to RNA polymerase.
Despite significant progresses in this field, cellular models are not yet able to provide a source of myocardial cells that will efficiently integrate and substitute damaged myocardial tissue.
These damage grades integrate the initial probabilistic evaluation with professional experience and judgment in order to determine potential damage to a particular structure at a particular location.
One problem with artificial hearts is that metal and plastic mechanisms can be difficult to integrate with tissue, or damage the blood because of their unnatural movement style.
