Our observations suggest that MCP-1 influences neuronal loss, which is integral to the progression of neurological disorders like Alzheimer's and Parkinson disease, via BBB leakage and macrophage polarization.
Glycoconjugates are important mediators of intercellular adhesion and membrane signalling, two processes integral to malignant progression and spread (Hakomori, 1999).
The observed interactions between TP53 and BRCA pathways are integral to the progression of tumourigenesis in breast cancer.
In addition, clock-regulated adipokines and nuclear receptors contribute to processes integral to disease progression, such as inflammation and T-cell activation.
The down-stream Osteopontin signals which interrupt the cell cycle, prevent apoptosis and promote cell survival are integral to tumour progression (Evan and Vousden, 2001).
Integral to cell cycle progression in yeast and animal cells are temporally controlled, progressive waves of transcription mediated by cell cycle-regulated transcription factors.
In addition to the cyclin and CDC gene families, other genes integral to cell cycle progression were also found.
Similarly, cancer stem cells are a source of new malignant cells that allow tumors to grow and spread, and they are integral to tumor initiation, progression, and metastasis.
Fibrosis is also integral to development and progression inflammatory airway diseases, including asthma, chronic bronchitis and bronchiectasis, where histological development of airway remodeling correlates with irreversible loss of lung function.
Obesity led to the accumulation of histone modifications associated with active enhancers at genomic loci downstream of signaling pathways integral to the initiation and progression of colon cancer.
