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Here it is hypothesized that minimization of the integral dose is advantageous in radiotherapy planning.
The direct product of dose, density, and volume forms a quantity called integral dose.
The key to these dose escalation strategies is to maintain a fixed integral dose to organs-at-risk.
The integral dose delivered to a volume of interest is the total energy deposited in that volume.
It has also been shown, however, to produce an integral dose that can be up to twice that resulting from a conventional megavoltage treatment.
Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer.
Similar(16)
Samples of isotropic LLDPE were oriented to draw ratios λ=6,9,11 and irradiated to integral doses between 35 and 500 kGy.
The mean and integral doses for all normal tissues were lower for 3D-CPT.
The integral doses deposited in the OARs and NT using the VMAT-S, IMRT and HT plans are given in Table 4.
All dosimetric data were very similar in both cases, both IMRT and VMAT had respected Radiation Therapy Oncology Group parameters for the PTV coverage, and the same applied to OAR sparing and integral doses.
In a study mentioned above comparing IMRT with 3D-CRT in patients with retinoblastoma, a 5-Gy treatment resulted in integral doses to the orbit bone of 69% using IMRT and 25% using 3D-CRT.
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