Sentence examples for integral checkpoint from inspiring English sources

Further, the level of phospho-Chk2, another integral checkpoint kinase, was reduced by ganetespib treatment.

In Schizosaccharomyces pombe the protein kinase Chk1 is an integral component of the checkpoint pathway, responsible for transducing a delay signal to the cell cycle machinery [1], [2].

However, since almost all the WS cellular phenotypes have a strong connection with defective DNA replicative processes, there is a wide consensus on a role of WRN as a replication caretaker, probably acting as an integral factor of the checkpoint response acting in the S-phase of the cycle.

Accelerated loss of telomere reserves and activation of cellular checkpoints appear integral to the decreased replicative potential seen in WS, as evidenced by the capacity of enforced TERT expression to impart unlimited replicative potential (Wyllie et al 2000).

The Aurora B kinase complex is an integral part of the mitotic checkpoint also in vertebrates [ 24 26].

FOXM1 is an integral component of the DNA damage checkpoint signalling network.

Because of its integral function as a cell cycle checkpoint during mitosis, MAD2 is also thought to have a function in paclitaxel resistance (Sudo et al, 2004).

Although the frequency of B cells expressing autoreactive immunoglobulin was lower than during active disease, the data suggest that early checkpoint abnormalities are an integral feature of SLE [ 50].

At many junctures during gametogenesis, translational regulation of germ cell mRNAs plays an integral role in meiotic cell cycle checkpoints for development of viable and mature gametes.

Agile also includes frequent checkpoints with the customer where the customer is an integral part of the development team which allows there to be frequent and timely changes to the software service or product that is in development.

At various points along the way, checkpoints are passed and officials bribed – with Thai border police often playing an integral role.