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Cluster analysis resulted in 4 clusters consisting of 35 to 81 subjects with differences in (1) mean fat intake, (2) standard deviation of intraindividual fat intake, and (3) fat intake trends over time.
After defining a distance matrix with 3 criteria to measure similarity between individual fat intake trends during childhood and adolescence (=fat intake pattern), cluster analysis was used to identify groups with similar individual fat intake pattern.
Modeled and empirical intake trends of ∑DDT are in good agreement.
With restricted water intake, trends were reported toward increased risk of dehydration and reduced risks of bronchopulmonary dysplasia, intracranial haemorrhage, and death, but these trends are not statistically significant.
To assess the plausibility of the intake trends for p, p′-DDE and p, p′-DDT extrapolated in steps 3 and 4 (solid and dashed lines in Figure 3A), we collected additional empirical intake estimates that were available only for ∑DDT (Vaz 1995).
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In LD, the trend in body burden is determined by both the intake trend and elimination kinetics.
The intake trend between the years 1970 and 2000 is exponentially interpolated in accordance with monitoring data (Alcock et al. 2002; Bignert et al. 1998).
However, as stated above, the slope of the CSTD function is solely determined by the rate constant of the intake trend, kdec.
However, because intake often changes over time, integration of the actual intake trend (rather than assuming steady state) would be desirable, but information about intake of measured individuals is rarely available.
Rather, it reflects influences of the intake trend, which in this case also includes preban intake, the elimination half-life, and the characteristic age of the sampled population [see Supplemental Material, Figure S2 (doi:10.1289/ehp.0900648.S1)].
Before 1970, the shape of the modeled adult reference intake trend, Iref(t), is defined relative to intakes in 1970 and 2000 based on information taken from historic emission inventories (Breivik et al. 2002) and exposure reconstruction studies for PCBs.
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