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As for many food components, the intake of metal ions can be a double edged sword.
Here, EDI = estimated daily intake of metal (mg/day), RfD = Oral Reference Dose (mg/kg/day).
An index more than 1 is considered as not safe for human health (USEPA [2002]).Daily intake was calculated by the following equation Daily intake of metal DIM = C metal × D food int ake B average weight (2).
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Recommended dietary intake of metals and metalloids.
The recommended dietary intake of metals and metalloids [26 28] is highlighted in the Additional file 1: Table S2.
However, information about dietary intake of metals is equally important for assessing their potential risk to human health.
The daily intake of metals (DIM) was calculated to averagely estimate the daily metal loading into the body system of a specified body weight of a consumer.
These data were used to calculate the daily intake of metals (DImetal) and target hazard quotients (THQ) values for all metals separately for females and males.
This includes not only intake of metals but another significant data as exposure frequency and duration, body weight and the oral reference dose (RfD).
Using daily intake of metals (DIM) and reference oral dose (R fD), the HRI value was obtained using the following equation.
Some studies have shown an increased risk of developing AD with environmental factors such as the intake of metals, particularly aluminium.
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