Rimonabant positively influenced dyslipidemia and insulin resistance not only by decreasing the food intake in the brain but also by blocking peripheral CB1 receptors.
In human beings, as in most vertebrates, the release of the intestinal peptide cholecystokinin (CCK) by ingested food plays a major role both in digestion and the regulation of further food intake, but the changes in brain function and their underlying activation mechanisms remain unknown.
We demonstrate that manipulation of Fto expression in the arcuate nucleus bi-directionally influences acute food intake in rats, implicating the brain and specifically the ARC in mediating at least some of the effects of FTO on energy balance.
There is a need for clear evidence of the relationship between early nutrient intake and brain development in preterm infants, so that improved nutrient regimens can be designed.
Our results are also interesting in relation to a previous study investigating the effects of ghrelin, the only known gut hormone which acutely increases food intake, on brain activity in normal-weight humans (Malik et al., 2008).
High salt intake in SHRSP significantly increased blood brain barrier impairment and early mortality, which were suppressed by treatment with aspirin independent of changes in blood pressure.
Several published studies [ 8, 15- 20] presented the evidence that inhibition or deficiency of Abcg2 or mdr-1 P-glycoprotein increases Aβ intake in cell models and reduces brain Aβ clearance in animal models.
We provide a demonstration that the combined administration of PYY3-36 GLP-17-36 GLP-17-36 GLP-17-36 humamidebjecto leads to similar reductions in subsequent energy intake and brain activity, as observed physiologically fasteding feeding.
► Coadministration of PYY3-36 GLP-17-36 GLP-17-36 GLP-17-36ood intamidend breducestivity ► The reduction in brain activity is notable in areas that control appetitive behavior ► Changes in food intake and brain activity are similar to that observed after a meal Published online: October 13, 2011 Obesity poses a major public health issue in modern societies.
Increased dietary intake of vitamin K, a fat-soluble nutrient involved in brain health and function, has been associated with better cognitive performance in older adults.
