During intact cerebrovascular regulation and during hypoxia-induced impairment of cerebrovascular regulation, changes in pial arteriolar resistance were accurately predicted by the proposed modeling method designed to assess changes of cerebrovascular resistance.
The corresponding effect in HS was short lived, which could be explained by intact glucohomeostatic regulation.
In the other 50% of tumours, where wild-type p53 is intact, the regulation of the p53 pathway is abnormal.
In those tumours in which the p53 gene is intact, the regulation of the p53 pathway may be defect [ 3, 4].
Expression of IMPDH II, the rate-limiting enzyme for cellular guanine ribonucleotide biosynthesis, prevents p53-induced asymmetric self-renewal, while leaving p53-dependent gene regulation intact [16], [18], [19].
Our results imply that mutations causing changes in the maximum production rate or the relative decay rate, but keeping the threshold of regulation intact, may have almost no phenotypic signature if the regulatory dose-response relationships are steep enough.
With all the changes the health care overhaul will bring in the coming years, it nonetheless will leave those regulations intact when new rules for flexible spending accounts go into effect in January.
These effects of emotion regulation remained intact even when controlling for baseline social functioning and Big Five personality traits.
As Ran releases an intact nucleotide, the redox regulation mechanism of Ran is likely to differ from the radical-based guanine nucleotide modification mechanism suggested for Ras and Rho GTPases.
Our results show that intact and synchronized circadian regulation of multiple steps of the entire bile acid metabolic pathway is essential to maintain its homeostasis, and that disruption of such regulation can result in liver stress responses and injury.
