The mice with a mutation in the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII), a synaptic protein enriched in the hippocampus, are appropriate for addressing this issue because the hippocampus of these mice is deficient in LTP but maintains intact postsynaptic mechanisms.
► Intact dopamine mechanisms are required for learning and posysynaptic plasticity.
Conversely, when autoregulation is intact, buffering mechanisms within the cerebral vessels take place to accommodate BP changes without disturbing CBF dynamics, a "time consuming" process.
Plasma hypothalamic corticotropin releasing hormone and pituitary adrenocorticotropic hormone levels were reciprocally decreased in both db/db and lean mice after exercise, indicating intact feedback mechanisms.
But in some cell types, intact apoptotic mechanisms can still permit oncogenesis if the cell has a high threshold for initiation of apoptosis (Savage et al. 2009).
Relatively intact autoregulatory mechanisms ensure that resuscitation from hypovolemic shock through volume provision is effective in recruiting vulnerable microcirculatory beds [ 13, 50, 51].
Thus, in two arthritis models, which are independent of adaptive immunity, intact effector mechanisms in myeloid pten -/- mice have been observed, highlighting the profound effect of PTEN in APC for the induction phase of immune-mediated arthritis.
Immunofluorescent localization of GFP-LC3 dots (alone and with lysosome-associated membrane protein type 1 (LasP1)), as well as electron microscopic examination, demonstrate that both autophagosomes and autolysosomes are increased after CLP, suggesting that intact autophagy mechanisms operate in the liver in this model.
The present study was designed to assess the possibility that sub-total ventral hippocampal lesions might leave intact a mechanism for only highly accurate navigation, whereas sub-total dorsal hippocampal lesions might leave intact a mechanism only for less precise navigation.
Non-surgical management is indicated for fractures with a clinically intact extensor mechanism and minimal step-off (<2 3 mm) and/or fracture displacement (<1 4 mm) [12, 22].
