Sentence examples for intact clock from inspiring English sources

We thereby questioned whether an imbalance of NAD+ levels in animals with an intact clock system would lead to defects in circadian rhythms.

When compared to wild type mice, ob/ ob mice also have intact SCN clock gene expression but abnormal peripheral clock gene expression, and these abnormalities were present prior to the onset of the metabolic phenotype.

Depletion of KLF15 in cardiomyocytes leads to a disorganized oscillatory behavior without phasic partition despite an intact core clock.

In contrast, resonance studies, as we use here, exploit the altered interaction between an intact biological clock and its external environment.

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This conclusion is also supported by accelerated functional senescence, and increased signs of neurodegeneration in per mutants compared to age-matched controls with an intact circadian clock.

While trunk somites are absent, somewhat irregular tail somites do form in spt mutants [ 14], concomitant with intact segmentation clock gene expression machinery [ 16].

Notably, both phase angle and phase coherence among peripheral tissues were similar to those in Fx/Fx control mice which possess an intact central clock.

DOI: http://dx.doi.org/10.7554/eLife.02510.013 In our knockout model, miRNA loss occurred in the hepatocytes of a liver that was under constant entrainment by a genetically intact SCN clock.

Notably, the behavioural abnormalities in tim>TAβ 42 and tim,pdf-gal80>TAβ 42 flies resembles the phenotype of tim>tetanus-toxin, in which synaptic blockade results in arrhythmic flies despite an intact molecular clock (Kaneko et al., 2000).

These results demonstrate that an intact central clock plays an essential role in driving normal circadian behavior as well as synchronized and robust circadian programs in peripheral clocks and that light and feeding act on individual peripheral clocks differently in the absence of a functional oscillator in the SCN.