Granada and Carlton have both said this would be an insurmountable block to the deal going through.
Craig, a father from Blackpool who is hoping to break the cycle of addiction which has plagued his family, first has to overcome deep-rooted issues, and Emily from Milton Keynes is given a second chance at rehab following a short ill-fated stint, but her difficulties present a seemingly insurmountable block.
This situation may arise, for example, at higher UV doses, in case repair synthesis factors become limiting or if the refilling polymerase encounters an insurmountable block.
Although ICLs had been previously thought to pose an insurmountable block to replication, our laboratory has recently demonstrated that human DNA pol κ and E. coli DNA pol IV can catalyze replication bypass of an ICL between the N-positions of dGs, which models the ICL formed by acrolein in a CpG sequence context (12, 16).
This is the ethical elephant in the CSR room; to Mr du Plessis it is just one of a number of "challenges", but to most anti-tobacco campaigners it is an insurmountable stumbling block, an absolute bar to dialogue.
Algebra, the reporters found, is an insurmountable stumbling block for many high school students.
He could not publish some other works and destroyed still others, and from 1938 to 1954 he suffered from an insurmountable writer's block.
The pressure to change Senate rules and strip Republicans of their power to filibuster certain judicial nominees "would be almost insurmountable" if Republicans block Millet's confirmation vote to the D.C. Circuit Court of Appeals, Leahy said at an event advocating Millett, currently a Supreme Court appellate attorney.
"The gridlock he faces from Republicans, especially in the House, is extremely obstructionist to his agenda, so when he runs into Democrats who are blocking him, it becomes insurmountable".
With the help of his family and Trixie, Speed defeats many brutal racers who have been bribed by fixer Cruncher Block (John Benfield) to stop him, and overcomes seemingly insurmountable obstacles to win the race.
But time, in fact, is running out for Mr. Trump's opponents, who must defeat him in several of the big states that vote over the next two weeks to block him from seizing an insurmountable lead.
