Second, the heterogeneity of the underlying molecular pathology means that pharmacologic agents aiming to reduce aggregation of abnormal proteins, such as alpha-synuclein, may be either inappropriate or insufficiently effective in a substantial number of patients.
Owing to insufficiently accurate prognosis predictions, however, a substantial proportion of breast cancer patients with breast cancer of inherently good outcome receive adjuvant systemic therapy without gaining any benefit [ 5].
Meta-analytical findings have indicated that a substantial number of patients do not or insufficiently respond to self-management interventions [ 25, 34].
Mr. Salmons called the Ninth Circuit's approach rigid and insufficiently flexible, adding that 15 to 20 seconds "is a substantial amount of time" to wait, given how easy it is to dispose of drugs behind a closed door.
With regard to counselling of individual patients, it has been suggested that the prostate specific antigen test is insufficiently sensitive for prostate cancer on the grounds that a substantial proportion of men with low concentrations have prostate cancer on biopsy.
In line with this observation, addition of glulisine, a rapid-acting insulin analog, showed a substantial improvement in HbA1c levels in patients who were insufficiently controlled with insulin glargine and oral antidiabetic agents.
V.I.P., which also makes muffin mix, dessert gel and flavored mashed potatoes, was cited for spilled food and for having substantial gaps at the doors of its loading bay and insufficiently screened windows, which could have served as potential entryways for insects and rodents.
Despite all known benefits, large groups of people are insufficiently active and inactivity is an important public health problem accounting for substantial healthcare costs [ 10– 10].
Substantial proportions of Palestinian women, and subgroups of Palestinian men, are insufficiently active.
But in 2010, Ms. Napolitano said the department would drop that standard, arguing it did not reflect a substantial buildup of agents and detection technology in recent years, and it was insufficiently flexible to account for the varying terrain and fast-changing conditions along the nearly 2,000-mile 2,000-mileborder, where mosouthwestl crossings occur.
There was a substantial variability for most of the parameter estimates, and the differences between the Insufficiently Active and Frequently Active groups only reached statistical significance (p < 0.05) for 4 of the 8 risk factors.
