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Changing the neoadjuvant chemotherapy regimen in insufficiently responding breast cancer is not a standard policy.
To select patients insufficiently responding to prior therapy, a two-step selection process was used.
The panel reserved IV iron + ESA predominantly for patients insufficiently responding to high-dose IV iron which is in accordance with the Gasché guideline.
Retinal edema and PEDs regressed significantly after switching to aflibercept in patients insufficiently responding to prior therapy with ranibizumab or bevacizumab.
The presented study aimed to evaluate eyes anatomically "insufficiently responding" to prior anti-VEGF therapy with ranibizumab and bevacizumab in a European population, with special focus on the prior treatment history.
5 However, there is evidence that aflibercept induces a further reduction in retinal thickness and pigment epithelial detachments in patients insufficiently responding to anti-VEGF therapy with either ranibizumab or bevacizumab.
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A proportion of patients do not respond, insufficiently respond or lose an initial good response to classic TNF inhibitors.
Meta-analytical findings have indicated that a substantial number of patients do not or insufficiently respond to self-management interventions [ 25, 34].
Low-dose MTX (≤15 mg/w) or MTX + LEF therapy was prescribed for patients responding insufficiently to the original DMARD s) therapy, intolerant to other DMARDs, in moderate to high disease activity or with prognostically unfavourable factors.
In patients responding insufficiently to MTX and/or other csDMARD strategies, with or without glucocorticoids, bDMARDs (TNF inhibitors, abatacept or tocilizumab, and, under certain circumstances, rituximab) should be commenced with MTX.
Biological agents have proven to be effective in patients responding insufficiently to MTX in randomised controlled trials (RCTs), not only in reducing disease activity and improving functional status, but in slowing radiological progression [ 9- 15].
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