The pivotal role of Treg cells in pregnancy and the clear association between their deficiency and pregnancy pathologies raise the enticing prospect of exploiting Treg cells in new therapeutic options for pregnancy complications where insufficient immune tolerance is implicated.
Further, while murine NETs were weak autoantigens in vivo, there was only partial overlap in the immunoglobulin G (IgG) and IgM autoantibody profiles induced by vaccination of mice with NETs and those seen in patients with SLE.Isolated in vivo exposure to NETs is insufficient to break tolerance and may involve additional factors that have yet to be identified.
In summary, two backcrosses using disomic strains indicated that disomy of chromosome XIII was necessary, but insufficient, for galactose tolerance.
In some cases, the level of stress gene expression appears to be insufficient to induce tolerance changes [ 24- 26].
Our results indicate that Hsp70 loss causes alterations of both inducible and constitutive stress gene expression that are ultimately insufficient for inducible tolerance of severe heat shock.
Isolated in vivo exposure to NETs is insufficient to break tolerance and may involve additional factors that have yet to be identified.
However, upregulation of such stress-responsive genes appears to be insufficient to induce tolerance of CaMBF1 transgenic plants to salt stress.
In elderly patients, the function of the systemic organ declined, especially their cardiopulmonary functional reserve, was insufficient, with low surgical tolerance.
The therapeutic application of regulatory T cells (Tregs) prolongs allograft survival in experimental models, but appears insufficient to induce robust tolerance on its own.
