For example, the integrin associated protein focal adhesion kinase (FAK) is a critical determinant of cell migration, yet similar to the small GTPases of the Rho family, the expression of FAK is insufficient to transform primary cells [ 42, 48].
Unlike the EGF receptor, overexpression of c-Src alone is insufficient to transform murine fibroblasts in culture or to sustain tumor growth in intact animals [ 15, 16, 17**].
Mutations that are insufficient to transform on their own may combine through cell fusion to result in carcinogenic transformation.
It fails to acknowledge that channelling more cash to schools and hospitals is insufficient to transform failing services.
It is important to note that expression of ΔDNMT3B4-del alone was insufficient to transform lung epithelial cells in our animal model.
Several studies showed that the murine direct reprogramming factors Gata4, Mef2c, and Tbx5 (GMT), or GMT plus Hand2 (GHMT), were insufficient to transform human fibroblasts into iCMs (Nam et al, 2013; Wada et al, 2013), indicating that the differences between mouse and human cardiovascular development need to be considered for optimal transdifferentiation to human iCMs.
Co-founder and Ashoka Fellow Javier Lozano is driven by one idea: to transform the traditional, insufficient and unjust model for diabetes care in Mexico where diabetes has become the leading cause of death.
Although statistics show crime falling since 2010, police forces were said to have an "insufficient understanding of the demand for services" and "will need to transform the service they deliver if they are to meet the financial challenge and address the changing nature of crime".
