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Despite their presence at all known MDS junctions, pointer repeats are short (average repeat length 4 bp between non-scrambled segments, 9 bp between scrambled segments [24]; current data still agree with these estimates) sometimes with mismatches, implying that pointer recognition alone is insufficient to direct accurate splicing.
Thus, although the extended 1 Kb PD1 promoter is functional and regulated in transient transfection assays [3], [24], it is insufficient to direct stable class I transcription in transgenic mice, suggesting that sequences downstream of the transcription start site are necessary in vivo.
Indeed, the Dia BD proved insufficient to direct apical targeting on its own.
Bipartite nuclear localization signals are interdependent basic domains, where the large monopartite-like domain is insufficient to direct nuclear import of a cytoplasmic protein in the absence of its partner domain [20], [24].
This indicates individual single-strand breaks are insufficient to direct HR across large regions.
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This competition effect is likely to reflect the relative indeterminacy of the cohort candidate set at the initial activation stage, where there is insufficient sensory information to direct selection to specific subsets of word candidates, and any member of the initial cohort is a potential recognition candidate.
The extension is necessary for protein targeting, but insufficient to re-direct TbRP2 to probasal bodies.
DTNs are wireless mobile networks that are particularly useful in sparse environments where the density of nodes is insufficient to support direct end-to-end communication.
Although a widely used method, the results from this field test are difficult to interpret in practice because (i) the fracture process in multilayer systems is very complex and only partially explored and (ii) field data is typically insufficient to establish direct causal links between test results and snowpack characteristics.
While the temporal resolution of fMRI is insufficient to provide direct support for this serial model, data including faster reaction times as well as earlier and greater event-related potentials to contour violations compared with contour-preserved differences provide strong evidence for such a serial search strategy [11] [13].
However, women whose self-collected specimens test positive for high-risk HPV (hrHPV) require additional triage testing because the specificity of assays for hrHPV is insufficient to justify direct referral for colposcopy in all cases [ 11, 12].
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