Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients.
In contrast, accidental hypothermia is associated with reduced concentrations of energy-rich phosphates and higher lactate levels as a result of insufficient tissue perfusion and failure of the organism to maintain normal body temperature.
We hypothesized that IAP elevation during pneumoperitoneum leads to insufficient tissue perfusion of the RAM and that the L/P ratio is increased in parallel as a signal of anaerobic metabolism.
However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport.
Multiple sclerosis (MS) and the disease model experimental autoimmune encephalomyelitis are neurodegenerative disorders whereby chronic destruction of the brain parenchyma results from an autoaggressive, immune-mediated inflammatory process and insufficient tissue regeneration.
Thirteen samples contained insufficient tissue for accurate analysis by histology.
We did not measure T or E2 in other regions because there was insufficient tissue.
The presence of dilated vessels could reflect veins subjected to arterial pressures, and such shunts could result in insufficient tissue perfusion.
In case of insufficient tissue, the cores were given the value 'no data'.
Another 34 had biopsies with insufficient tissue, an indefinite diagnosis or a cytology-based diagnosis.
Multiple biopsies are recommended to help reduce the chances of insufficient tissue for histological assessment.
