However, instability of peptides and insufficient N-terminal processing of proteins in E. coli often leads to low yield and the need of time-consuming purification procedures for pharmaceutical grade purity.
Interestingly, the combination of cdk4, hTERT, and Ras was insufficient to inhibit terminal differentiation of keratinocytes; the skin equivalents produced a stratified squamous epithelium that cornified in three weeks; the squamous cells lost p63 expression and gained involucrin staining similarly to the control and immortalized keratinocytes.
The available tools for the analyses of the use of such terminals offer insufficient support for decision-making on the location and design of these terminals from the sustainability perspective.
Exclusion criteria for patients applied at baseline are: assistance by an outpatient geriatric team for cognitive problems, terminal illness, insufficient command of the Dutch language, participation in other research projects, and institutionalization. Exclusion criteria for caregivers are: terminal illness and insufficient command of the Dutch language.
This changes the results from "significant" to "not significant," and we therefore have insufficient evidence to suggest terminal digit errors in the p values reported in Nature articles.
One such arterial malformation, human single umbilical artery (SUA) syndrome, in which one of the two umbilical arteries is absent in the cord, is believed to be caused by insufficient irrigation of the terminal portion of the embryo.
Because of the nonlinear nature of the PK data and insufficient data for the terminal phase of the concentration-time profile, the half-life of AMG 108 could not be determined.
The fact that some of the patients had advanced Alzheimer's disease, some other type of brain damage or a terminal disease received insufficient scrutiny.
In a larger realm, these results also suggest that focusing on neurotransmitter function solely at terminal fields is insufficient to understand behavior.
Exclusion criteria were serious psychiatric disorder, current alcohol or substance abuse, serious comorbidity such as terminal cancer or insufficient Norwegian language skills.
The terminal elimination phase could not be estimated properly for several patients treated at the lower dose levels (up to 0.4 mg) due to insufficient data points in the terminal phase.
