Sentence examples for insufficient targeting from inspiring English sources

However, exosome insufficient targeting capability limits their clinical applications.

However, rapid immune clearance, insufficient targeting capacity, and poor cytoplasmic delivery efficiency substantially restrict their clinical application.

However, ADCs classically target overexpressed and internalizing antigens at the surface of cancer cells, and in solid tumors are associated with poor tumor penetration, insufficient targeting in heterogeneous tumors, and appearance of several resistance mechanisms.

This combined with the insufficient targeting of compensation payments to areas where special measures are needed leads to an unsatisfactorily low impact of agri-environment measures compared to other driving forces that stimulate the intensification of farming.

In fact, the major limitation encountered in our previous study was the insufficient targeting of CD44highCD24lowHER2low cells either with trastuzumab alone or in conjunction with NK cells.

In Pompe disease, a metabolic myopathy caused by defective activity of acid α-glucosidase (GAA), insufficient targeting of the therapeutic enzyme to the major sites of storage and pathology, i.e. heart and muscle, has also been observed.

Specifically, the most representative points called "exemplars" and the preferences in the source domain are considered for helping in the construction of the high-quality clustering model for insufficient target data.

Hansen told reporters at a press conference yesterday that he hoped the paper to be published online this week would influence global climate talks this December in Paris and encourage negotiators to reconsider their goal of keeping warming to less than 2°C above preindustrial levels, a laudable but insufficient target, some scientists say.

Despite producing gigabases of sequence per run, these technologies still present obstacles in resequencing and de novo assembly applications due to biased or insufficient target sequence coverage.

While the reasons for the clinical failure of tarenflurbil are unknown, low penetration across the blood brain barrier (BBB) and, consequently, insufficient target engagement in the brain may be likely explanations [ 21].

Unfortunately, several clinical trials based on these approaches have been unsuccessful, raising the question of whether failure was due to insufficient target engagement, trial design, or the amyloid hypothesis.