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LRP may not work in some individuals for which there is insufficient surrogate information (e.g. due to a recombination in a gamete), or for which surrogate information is inconsistent.
However, to draw reliable conclusions about intravascular volumetric effects from total infused amounts over time guided by often insufficient routine surrogates (for example, blood pressure, heart rate) is problematic.
This surrogate for exposure is insufficient especially when causative exposures occur largely in areas other than residence locations, such as in areas related to occupational or recreational activities.
However, the immunohistochemical (IHC) detection of Ki67 as a surrogate for proliferation was recently deemed insufficient to clearly distinguish luminal A and B [ 8].
Is Louise a surrogate for Emma?
"He's a great surrogate for us.
Now comes a surrogate for that experience.
"But it's not a surrogate for preparation," he said.
"My boss is in Palm Beach as a surrogate for Gore".
I was the surrogate for my then boss, President Jimmy Carter.
So maybe being black is a surrogate for being overweight".
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