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An inappropriate or insufficient selection of time scales may lead to improper or sub-optimal bias corrected outputs, especially when persistence attributes across a range of scales are of interest.
As the hypermutant frequencies were in the ∼10−2 to 10−5 range, deamination may represent an insufficient selection pressure to cause the virus to adapt, unlike the lentiviruses that evolved a vif gene.
The genetic programs continue to be executed later in life because there is insufficient selection to change or stop them.
Even in vertebrates, DNA sequences conservation is low and suggests that most lncRNAs are not functional due to insufficient selection pressure.
With regard to the important involvement of co-stimulatory ligands expressed on plasma cells and memory B cells in SLE, it has been shown that T and B cells from SLE blood spontaneously express CD154 [ 36], suggesting a potential abnormal release of activated lymphocytes from the GCs or insufficient selection permitting abnormal egress of memory B cells into the blood.
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One possible explanation for this is insufficient size selection with AMPure beads.
Our prior study showed that insufficient confounder selection led to high false positive rates [ 31] and therefore we designed the two-step LASSO regression (step 1 of the proposed methodological framework) to select more associated confounders.
Flies heteroallelic for ry and ry have 2.5% of the wild-type level of XDH activity, which is sufficient for wild-type eye color but insufficient for survival on purine selection (Gelbart et al. 1976).
In recent years there has been much emphasis on 'research waste' caused by poor question selection, insufficient attention to previous research results, and avoidable weakness in research design, conduct and analysis.
Note that one population examined previously (Shitoko) was excluded because the small sample size was insufficient for natural selection analyses.
Other weaknesses are insufficient control for selection bias, inadequate sample sizes to assess cancers with low incidence, and lack of appropriate comparison populations.
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