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Hurdles and bottlenecks are well known eg, small numbers of patients, the complexity of developing targeted agents and their biomarkers for selected patients, limitations of US and EU regulations for paediatric medicines, insufficient return on investment, and the global economic crisis facing drug companies.
For most healthcare companies, a profit of $38/month per 100 patients would be an insufficient return on capital for them to pursue this business.
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An important financial impediment is insufficient return of investment.
Constraints however still exist due to the insufficient return of qualified personnel and insufficient utilization of provided services.
Constraints however continue to exist specifically due to an insufficient return of qualified personnel.
"If lending hasn't grown at the same rate as savings, which seems likely, Investec is probably sitting on surplus cash earning an insufficient return to pay its competitive savings rate".
The Commission on AIDS in Asia found that almost 90percentt of all investment in prevention went to areas with insufficient returns [ 20].
New Basel rules will require banks to hold more capital, and that will presumably reduce the rate of return on already insufficient profits.Coping with this mess is a new chief executive, Michael Corbat, and a relatively new and newly assertive chairman, Michael O'Neil, who doubtless want to set their own course.
To date, the return on capital from private renting has been insufficient to attract investors, which coupled with the relatively high management costs compared with commercial property has made the sector unattractive as a financial opportunity.
Additionally, across sectors, about 20% of respondents continue to identify insufficient maturation of the technology and concerns about a lack of return on investment as limitations.
When recruitment is protracted and/or insufficient to achieve desired power and samples are restricted to sub-sets of the target population, the return on large-scale investment in research and the generalizability of RCT evidence are compromised.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com