Unfortunately, its cytostatic effect in therapeutic doses is frequently insufficient (monotherapy response rate of only 18-29%); but the use of higher doxorubicin doses is limited by the development of systemic toxicity, especially cardiotoxicity.
Second, the response rate was insufficient and the representativeness of the sample was problematic.
The recordings of personal questionnaire distribution in the institutions were insufficient for calculating response rates.
To conclude, there is insufficient evidence to suggest a TTP, response rate and toxicity advantage in administering 5FU in combination with other chemotherapy agents over 5FU alone.
Several studies show that one can not assume that higher levels of response provide different and 'safer' results, and concentrating on the response rate is therefore insufficient to determine the quality of survey data.
It is probable that some of this toxicity could be ameliorated by dose reduction, but this would likely further compromise a response rate that is already insufficient to warrant further research.
The handling of UI is, however, unclear because of low response rate to the questionnaire and insufficient data available from the county's health registry.
GPs management of UI in a Danish county may be reasonable, but low response rate to the questionnaire and insufficient registry data made it difficult to evaluate the impact of different UI initiatives.
