Reasons for failures included sub-optimal probe synthesis and insufficient resolving of assay traces, potentially due to nearby hidden SNPs or copy number variants (CNVs).
In the majority of our selected spots, multiple proteins were identified per spot due to similar migration patterns and insufficient resolving power.
Similarly, our attempts to measure the amount of ATP consumed per bp of DNA translocated have had insufficient resolving power, given the speed of translocation (Graham JE and Sherratt DJ, unpublished data).
Reconstructions from embryos older than 20 somites had insufficient resolution to resolve the finest vascular details in the complete embryo, but were sufficient to position larger vessels and overall structure (data not shown).
However, superficial burns in the epidermal layer cannot be reliably evaluated with OCT because of insufficient resolution to resolve individual cells and reliably determine tissue damage.
Although the SAXS data have insufficient resolution to resolve multiple closed states, and may include contributions from high-order non-covalent oligomers, linearly combining the SAXS data calculated for the closed and open states at 70% and 30% and without further refinement, we were able to recapitulate the experimental SAXS data with a χ value of 1.24.
The NE was used to determine cis to trans direction because the resolution was insufficient to resolve the protein coats on the vesicles that are normally used to determine the Golgi polarity.
Confocal microscopy identified peripheral immunostaining for RyR (173), but the resolution is insufficient to resolve whether RyR were in the PM or within ER lying close to it.
Identification of intact proteins from tissue is difficult due to the often limited mass resolution which is insufficient to resolve the complexity of tissue samples.
The Oppenheimer Siddur is very small13 and high resolution digital images alone proved insufficient to resolve these questions.
The spatial resolution of these observations is insufficient to resolve the structures of such ductile shear zones.
