However, treatment failures in patients with advanced disease, insufficient response (recurrences and resistance) as well as late toxicity of the currently used chemotherapy – including second malignancies, cardiovascular toxicity and infertility – requires improvement in standard options for treating HL [ 23].
Unless the disease is extensive and involving bronchial glands as well as the mucosal surface [33], there may be insufficient risk of recurrence to warrant any further therapy [32,34].
Several authors recommend early surgical intervention, but in their report the mean follow-up is short and appears insufficient to assess for recurrence [10].
Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual death.
Just making a slot without thoroughly removing residual nucleus material therefore seems insufficient to avoid early recurrence of disc extrusion.
Manometry pressures, timed swallow, or symptoms alone are insufficient tools to diagnose recurrence and repeat PD or proceed to surgery.
BCVA alone is insufficient to detect a recurrence of activity of the neovascular membranes in neovascular AMD.
However, clinical assessment and CEA measurement alone are insufficient, as identification of recurrence before the onset of symptoms may allow earlier and more effective treatment, it is also well recognized that recurrence may occur in the absence of rising CEA.
The results not only demonstrated improved bone mineral density (the primary endpoint) with immediate ZA treatment, but showed a benefit for DFS - in the ZO-Fast trial at 48 months [ 6] and in the Z-Fast trial at 12 to 48 months but not at 5 years [ 7] (the two other similar trials (E-ZO-Fast and N03CC) had insufficient data to evaluate recurrence at 12 months [ 8, 9]).
Administration of bicillin-5 alone in contemporary conditions of increasing antibiotic resistance and immunodeficiency of population is insufficient to prevent the recurrences of erysipelas.
Furthermore, as we did not investigate the classification of the recurrent stroke, the explanation about the relationship between CRP and stroke recurrence may be insufficient.
