The yields were identical when the polymerization was conducted at 60°C and 80°C, but the yield decreased at 40°C, probably by the insufficient reactivity.
The inability of the compound to exert its protective effects in the ATGL-deficient animal model may originate from insufficient reactivity or steric hindrance in a lipid-overloaded cellular environment.
The crossreactivity and lack of sensitivity of the whole CAIII protein suggests the presence of multiple epitopes sharing common regions with other proteins, as well as the presence of immunodominant epitopes that surpass the response to the M12 critical epitope, which may have generated either false positive results or an insufficient reactivity.
Insufficient specificity (cross-reactivity), interference phenomena and poor robustness remain weak points.
The most critical design errors were poor layout (17%), insufficient consideration of chemical reactivity and incompatibility (16%) and incorrectly chosen process conditions (16%).
As seen from patient m46′s CAP results and other, undisclosed, data, CCD inhibition does not necessarily lead to all or nothing situation, due in particular to insufficient inhibition of the reactivity against honeybee venom.
Preparations based on unmodified milk of milks from other mammalian species (sheep, buffalo, horse, camel, or goat milk) or unmodified soy or rice milk should not be used to treat CMA because of their high rate of possible allergenic cross-reactivity and insufficient nutritional value [ 18].
It seems, however, that selection for decreased levels of fear and aggression toward humans, as proposed by the emotional reactivity hypothesis, may be insufficient in accounting for higher interest in and cooperation with humans [5].
The development of QMFFs also offers an opportunity to extend the accuracy of biochemical simulations to areas where classical force fields are often insufficient, especially in the areas of spectroscopy, reactivity, and enzyme catalysis.
In fact in this region, homology is limited to stretches of three amino acids or less (with only one region of CRX and OTX1 sharing four amino acids), which is an insufficient length to likely support significant cross-reactivity of the antibody via a shared epitope.
Nitrogen-, oxygen-, sulfur-, and selenium-based oxidants were all insufficient in effecting a transformation plagued by low reactivity, selectivity, and stability.
