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Exact(4)
In this situation, as a result of ppGpp-deficiency due to the mutations, the transcription from the stress-responsive promoters can be impaired, partially due to the insufficient pool of free RNA polymerase core molecules that could bind to other σ factors related to stress tolerance, such as RpoN or RpoS (Potrykus and Cashel 2008).
Yet over two-thirds of these jobs could go unfilled due to the insufficient pool of college graduates with computing-related degrees.
We propose that this reduction could result in insufficient pool of antigenic peptides for presentation in the foetal thymus and T1D susceptibility (Supplemental Figs. 2, 9).
This complex spectrum of progressive ovarian abnormality is largely related to the size of primordial germ cells (PGCs) pool, where prepubertal onset might reflect a complete lack of germ cells since birth causing a failure in the maintenance of ovarian somatic structure and postpubertal onset would reflect a variably insufficient pool of oocytes.
Similar(56)
Unfortunately, there were insufficient pooled data on these outcomes for meta-analysis.
There were insufficient patients to improve further on matching for sex so the method was only partially successful due (at least in part) to an insufficiently large pool of patients from which to draw an ideal comparison group.
In the proposed algorithm, an individual's fitness is only computed if it has insufficient similarity to a pool of fuzzy granules whose fitness has already been computed.
In the absence of EBP1 overexpression, IPA-3 inhibition of PAK1 activity is insufficient to allow the pool of non-phosphorylated EBP1 to reach this critical level.
For example, easing entry restrictions for potential entrepreneurs may result in a large pool of entrepreneurs with insufficient entrepreneurial ability and skills, which in combination with asymmetric information about their skills and ability can result in a general contraction of finance from banks (who do not want to lend to entrepreneurs with poor ability) (de Meza and Webb 1987).
It is remarkable that our two patients with homozygous NANOS3 mutation have presented with primary amenorrhea, perhaps indicating more severely PGC-depleted ovaries, while their heterozygous mother had difficulty to conceive, which could represent a manifestation of insufficient PGC pool size.
New evidence suggests that the global charity model, to help people help themselves temporarily rather than to create a sustained pool of redistributed funds, has provided an insufficient response to the challenges preventing MDG progress.
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Justyna Jupowicz-Kozak
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