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The remaining 28 were not classified due to refusal of medical record release (N=6) or insufficient pathology information for classification (N=22).
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Of the 600 Thal amyloid Phase 1 2 cases, 416 (69%) had insufficient plaque pathology for Alzheimer's disease diagnosis (i.e. <30 plaques/field), with only 22/416 having a Braak NFT stage ≥IV (i.e. tangle predominant dementia cases) (Janocko et al., 2012).
Although many studies have focused on stressful events and chronic stress, the intensity or the number of stressful events is insufficient to cause pathology and illness.
Is it feasible that low levels of human anti-DNA antibodies, as secreted by the CHO cells in our experiments, are sufficient to cause the clinical outcomes of proteinuria and early death but insufficient to cause pathology observable by histological change?
Plausibly, the enduring limitation of AEDs' efficacy derives from the insufficient understanding of epileptic pathology.
Cases with ambiguous histologic diagnosis or insufficient data regarding the pathology were excluded from this analysis.
Insufficient bone volume Acute periapical pathology (tooth sensitive to percussion) Existence of non-treated generalized progressive periodontitis Chronic acute systematic disorders (e.g., uncontrolled diabetes, hemorrhagic diatheses, general or auto immunodeficiency) Patients refusing to give their consent for the use of their data.
Pre-operative FNAC and CB are insufficient to accurately diagnose significant pathology associated with RS or CSL.
The examination of patients for anti-CL and anti-β2 glycoprotein I antibodies and lupus anticoagulant is insufficient to understand the essential pathology of antiphospholipid antibody-related thrombosis.
However, if patients were not treated surgically or if the pathology report was insufficient, diagnostic images were used to determine size.
However, the known functions of the proteins mutated in disease are insufficient to fully explain the pathologies observed without assistance from partner proteins that thus far have not been identified.
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CEO of Professional Science Editing for Scientists @ prosciediting.com