In most cases, failure was due to insufficient long-term stability of the adhesion of such coatings on implants in vivo.
In the case of adalimumab and infliximab, respondents cited a number of reasons not to prescribe these treatments, including cost, insufficient long-term data, concerns with safety and tolerability, and difficulty of administration.
While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain elusive due to insufficient long-term self-renewal and inadequate differentiated progeny functionality.
There are however currently insufficient long-term experiments to support the contention that large amounts of carbon could be sequestered in soils and biomass; therefore, soil and biomass carbon sequestration are not accounted for in the current Australian Government savanna burning methodology which only assesses CH4 and N2O dynamics.
This task demonstrated that the RAAF had insufficient long-ranged transport aircraft to simultaneously support overseas deployments and meet the force's domestic requirements in Australia.
Fang and Neufeld state that "80% of open source software projects fade away due to insufficient long-term participation" [ 51].
The OECD reports that insufficient long-term care services in Norwegian municipalities regularly require hospitals to take care of elderly people with no acute medical need [ 21].
The conventional disease-modifying anti-rheumatic drugs (DMARDs), most commonly methotrexate (MTX), non-steroidal anti-inflammatory drugs (NSAIDs) and steroids, can inhibit local inflammatory symptoms but have little or insufficient long-lasting systemic effects.
The fear that early thrombosis and late luminal loss due to intimal hyperplasia formation potentially lead to insufficient long-term patency rates can explain the reluctance on implanting stents in these small-diameter vessels.
In fact, only moderate success is reported for reintroduction projects due, for example, to insufficient long-term monitoring following reintroduction and/or lack of understanding of the underlying reasons for decline in existing plant populations (e.g. Godefroid et al. 2011).
