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A single gene assessment requires high RNA quality from fresh (frozen) tissue, however, and might be insufficient in cases of more heterogeneous RNA quality (for example, RNA from paraffin-embedded tissues).
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The cell surface expression of death receptor (DR 4 or DR5 is a prerequisite for TRAIL-mediated apoptosis, but is insufficient in case of blocked intracellular pathways.
This makes the development of a crash prediction model costly and unaffordable in cases of insufficient accident statistics [15].
In cases of insufficient liquid irrigation, solid particles can cause clogging of the filter and unplanned, costly shut down of technologies for the maintenance.
In cases of insufficient blood quantity or excessive application pressure, air bubbles develop and the sample must be rejected.
Kampo is used primarily; in cases of insufficient improvement acupuncture and moxibustion from Chinese Medicine (CM) are used.
Parallel masitinib-treatment groups at different initial dose levels were studied to determine the optimal starting dose of masitinib, with dose adjustments possible in cases of insufficient response.
Le Pimpec Barthes et al. described the effectiveness of contralateral TS as an additional treatment in cases of insufficient pain reduction after unilateral TS [ 24].
Furthermore, stem cell boosts with or without the use of a preparative regimen can be performed in cases of insufficient donor cell engraftment after re-transplantation.
Since dose adjustment was permitted at weeks 4 and 8 in cases of insufficient treatment response, the dose at the time of first response was also analysed.
In cases of insufficient spontaneous self-expansion after placement, the stent was dilated to the estimated diameter of the treated vein.
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