Or when plans announced with fanfare turned out to be insufficient or hit practical obstacles.
This indicates that the stringent promiscuity filters applied here might, for some experimental conditions, be insufficient to discard unspecific hits, and additional control assays might be necessary to remove non-selective chemical hits.
First, since not all dsRNAs are effective in knocking down the target genes, failure in validating the original positive hits is insufficient for validating FPs.
Their hit single "Insufficient Fare" stirs up pit antics like you don't even know.
With the highly heterogeneous chemical components in the CREDO database however, the lack of discrimination between atom types becomes apparent and the USR approach is found to be insufficient - top-ranked screening hits often contain inappropriate compounds for the given query molecule such as carbohydrates and solvents that are frequently found amongst crystal structures.
Ideally, mapping time is largely spent on the matching and validation of true alignments, but if the seed weight is insufficient, the examination of random hits will dominate the running time.
The remaining 34% either showed insufficient similarities to any proteins (no hits, 25.9%) or hit proteins without a GO identifier (unclassified, 8.1%).
The implication of these statements seems to be that the 2-hit hypothesis is insufficient to explain NAFLD development in all cases, yet in the same paragraph, the "second hit" is referenced again.
A vertical approach works for a while, and then it hits the ceiling of insufficient health workers and dysfunctional health systems, particularly in countries with high HIV prevalence.
Not only is New York Mayor and media business mogul Michael Bloomberg hitting President Obama on insufficient gun control... today, news that a key deputy mayor is leaving his job.
