There are various possibilities, how cognitive impairment may influence further clinical course: On the one hand, as cognitive impairment is linked to poor functional outcome, insufficient functioning resources may in turn lead to higher stress levels resulting from insufficient coping with life-events and daily hassles.
Taken together it appears quite clear that latent hyperprolactinemia is a, if not the major cause of premenstrual mastodynia, mastalgia and infertility due to insufficient function of the corpus luteum.
Late appearance and functional defects of T cells in hepatitis C virus infection might be the result of the rapid increase of the viral load that could create the conditions for exhaustion of the adaptive response or reflect an insufficient function of the innate immune response.
The loss of one functional copy of these essential splicing genes, without compensating expression, may lead to insufficient function in supporting photoreceptors especially because of their high demand for mRNA expression and protein synthesis.
This then often results in chronic lung disease and insufficient function of the exocrine pancreas.
In this model TRPC4 and C5 seem to be induced after insufficient function of SR calcium accumulation [ 22].
In contrast, recombination can restore function to genomes with distinct defects and so might be productively induced under circumstances of insufficient function or DNA damage.
There is ample evidence that insufficient functioning of the protein C pathway contributes to the derangement of coagulation observed in sepsis [ 5, 6].
Both mutations resulted in PTC before the last exon, thus insufficient functioning due to haploinsufficiency was the most probable cause in these two families.
Both mutations result in premature termination codons before the last exon, thus insufficient functioning due to haploinsufficiency instead of aberrant function of the mutated proteins seems to be the most probably reason in these two families.
