As far as the biomedical application is concerned, traditional aliphatic polycarbonates usually suffer from the strong hydrophobicity, deficient functionality, and insufficient compatibility with cell/organs.
That's a tremendous opportunity to invest and innovate when you consider the fact that nearly half of all marketers in a recent IAB survey cited "insufficient availability and functionality of supporting technology" as a key obstacle to deriving value from data-driven marketing.
Although not directly involved in mitochondrial function, it provides defence against oxidative stress that can be relevant to mitochondria, as demonstrated by conditions where mitochondrial function is affected by insufficient or aberrant catalase functionality.
Additionally the existence of different levels of regulation, including translation, protein maturation and degradation rate, may confer gene expression insufficient evidence of gene functionality [ 14, 15].
Therefore, KDM2B dependent targeting of the PCGF1-PRC1 conplex on its own is insufficient to account for the functionality of PRC1 in vivo.
Nevertheless, it should be pointed out here that the presence of neural markers alone is insufficient to confirm full neuronal functionality [ 9].
Using an experimental system for monitoring the dynamics of arginine methylation, and through short hairpin RNA-mediated knockdown of CARM1 mRNA transcripts (90% reduction) in MCF7 breast cancer cell lines, the authors demonstrate that the RNA interference technique is insufficient to reduce CARM1 methyltransferase functionality.
However, because a gene can have multiple functions, such a single network may be insufficient to represent all the co-functionality relationships between genes.
1.4 Prioritization results were insufficient: Some groups hardly used the like functionality (see Table 2).
Our results demonstrate that mere architectural description is insufficient to find root systems of optimum functionality.
Patients who go on to be chronically infected often do not lack a cell-mediated response initially, but there is evidence that the timing, persistence and functionality of the response are insufficient to control HCV [21,48,49].
