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First, since duloxetine is 90 95% plasma protein bound (Lilly Research Laboratories, data on file), it could be argued that insufficient free plasma concentrations of duloxetine for NET inhibition were achieved peripherally.
It is shown that by reducing precursor open porosity from standard values of ≥25% to ∼11 12%, such that there is insufficient free volume to permit substantial incorporation of calcium, a new reaction pathway for electro-deoxidation is created.
In addition, the degradation became decreased with increasing the amount of sewage sludge, caused by insufficient free spaces between the substrate mass for feasible microbial activities.
On the contrary, in the case of insufficient free space in a relay buffer, the proposed schemes do not allocate any subchannel to the corresponding link from the BS and this way, they prevent data transmissions to that buffer.
Because of its insufficient free concentration in biological fluids, the bacterium employs strategies to obtain iron in complex forms.
The observed lack of DNA uptake by gut bacteria might also be related to the lack of expression of bacterial competence inside the gut, insufficient free DNA concentrations, suboptimal biochemical conditions for transformation that the use of assay methods were not sensitive enough for detecting low levels of transformation.
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However, if the active hydrogen is insufficient, the free radicals themselves will aggregate to produce macromolecular substances.
A Waitrose spokesperson said the supermarket sometimes used imported eggs when there were insufficient British free-range eggs available on the market to use as an ingredient in own-brand products.
He worried that the human race had insufficient wisdom to free the primal energies.
A constraint satisfaction neural network model (the consonance model) simulated data from the two major cognitive dissonance paradigms of insufficient justification and free choice.
Providers will have bigger wage bills, owing to the introduction of a national living wage; state-funded social care is being cut and funding is insufficient for expanded free provision in childcare.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com