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This suggests that metformin-dependent cellular energy depletion results in insufficient flux of ATP required to drive energy-consuming hepatic gluconeogenesis (Fig. 1) [ 31].
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Insufficient carbon flux through the PEP-to-fumarate branch or elevated carbon flux through the glyoxylate shunt lowers the observed yield.
The search is terminated when there are insufficient downstream fluxes to achieve DoF-1 IFF.
It is possible to reduce traversal down search trees that cannot yield any EFMs due to insufficient downstream fluxes to form DoF-1 IFF.
Such an accumulation implies that the activity of HMG-CoA reductase was insufficient to balance flux in the engineered pathway.
However, there was a low current density under the rib and at the cell edge because of an insufficient reactant diffusion flux.
It was subsequently demonstrated that the activity of tHMGR is insufficient to balance flux in the heterologous pathway leading to a pathway bottleneck [10].
A possible reason could be that there was less substrate in media provided for FA synthesis, thus, the addition of hormone to the cell culture provided was insufficient to increase flux through the pathway.
Simulation shows that usual practice with assignment of only gas velocity and solids flux is insufficient for determination of the dense bottom height in a riser, and this can be attributed to the absence of another independent variable, solids inventory or imposed pressure drop.
The decrease in ethanol production and reduced electron flux may generate insufficient NAD+ to ensure normal cellular metabolism.
This stage occurs when PAR absorbed is insufficient to generate an electron flux to satisfy Rubisco capacity.
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