Our study highlights the role of insufficient evaluation of cases in which surgery is cancelled after the patient has entered the operating room.
Those studies that do suggest an increased mortality have serious methodologic flaws such as small numbers of heterogeneous patient populations, inappropriate use of the PAC, insufficient evaluation of intensivist expertise and nonprotocol-driven therapeutic strategies in response to PAC data [ 17, 18].
However, the hypothesis of its sister-group relationship with the non-polyneopteran lineages was either based on an insufficient evaluation of very incomplete morphological data or an artefact mainly caused by parallel reductions of some of them (e.g. number of Malpighian tubules or tarsomeres) [ 35].
One possible cause of recurrence may be insufficient preoperative evaluation of the lateral and vertical extent of the disease.
We believe that tissue observation using only general stains such as HE or Alcian blue is insufficient for evaluation of the present results of basic research and that collagen typing through immunostaining is essential.
Because of insufficient volume, further evaluation of the positive sample for neutralising antibodies was not possible.
Self-assessed measures of exposure and degree of annoyance have been questioned in previous studies, mainly due to insufficient evaluation against objective measures and the risk of bias when using surveys [ 33].
However, the ClogP and PSA alone have proven insufficient for the accurate evaluation of the BBB permeation, since they correlate poorly with the logBB values in our previous studies.
The inconsistent results observed in studies on rapid response system effectiveness may also be due to insufficient time allowed for the evaluation of the study endpoint.
