Kaplan Meier curves for time to discontinuation due to insufficient efficacy (insufficiency) and adverse events (AEs) were generated.
Tricyclic antidepressants (TCAs) were not recommended because of insufficient efficacy evidence, as well as adverse events.
Discontinuation before planned completion of the study implies insufficient efficacy or unacceptable adverse effects.
Despite this achievement, they have two major drawbacks: insufficient efficacy for in vivo gene transfer and insertional mutagenesis.
However, due to insufficient efficacy of these conjugates, improved GnRH antigens, like peptides existing of repeats of the GnRH amino acid sequence, have been designed.
Although kinase inhibitors (KIs) have revolutionized the treatment for certain types of malignancies, some major medical needs remain unmet due to the relentless advance of drug resistance and insufficient efficacy of mono-target KIs.
The insufficient efficacy of oral vaccines is partly due to antigen breakdown in the harsh gastric environment, but also to the high tolerogenic gut environment and to inadequate vaccine design.
(1) "Unsuccessful" is defined by (a) no or insufficient efficacy (based on patient report and recordings in a headache diary), (b) intolerable adverse effects, (c) contraindications.
In large tumours, often heterogeneity of receptor distribution [24] is observed, resulting in insufficient efficacy of the treatment and leading to probability survival of tumour cells.
In consequence, this lack of predictive models leads to unexpected adverse drug reactions or insufficient efficacy of the drugs which are observed in the late clinical trials at high costs.
The efficacy results of any CAM treatment and the number of CAM modalities used in our study indicate that the patients seek a 2nd or 3rd CAM treatment, if the previous modality failed or had insufficient efficacy.
